Enhanced depletion of MLL-fusion proteins in acute leukemia: potential for improved therapeutic outcomes
Abstract Rearrangements of the MLL (KMT2A) locus are associated with aggressive leukaemia of both myeloid and lymphoid lineages, that present profound altitude sunscreen therapeutic challenges in pediatric and adult patient populations.MLL-fusion genes resulting from these rearrangements function as driving oncogenes and have been the focus of rese